muscarinic receptors

Muscarinic cholinergic receptors

The acetylcholine muscarinic receptor belongs to the class of serpentine receptors that transmit signal through heterotrimeric G proteins .

The muscarinic receptor family

Their ability to bind the alkaloid muscarine . muscarinic receptors were initially divided pharmacologically into M1 and M2 types, based on differences in their sensitivity to pirenzepine .

muscarinic receptors
muscarinic receptors

Which has proven to be a selective M1 receptor antagonist. 

It has been shown that stimulation

The M1 receptor activates phospholipase C ( PLC ), leading to the release of the second messenger inositol 3-phosphate and subsequent mobilization of intracellular calcium . 

It has also been shown that inhibition of the M2 receptor suppresses the activity of adenylate cyclase , leading todecrease in intracellular cAMP levels . 

Muscarinic receptors can be divided into subtypes according to.

  • Their ability to mobilize intracellular calcium (m1,m3,m5) or inhibit adenylate cyclase ( m2 ,m). 
  • The m1, m3, and m5 receptor subtypes activate phospholipases A2, C, and D, tyrosine kinase, and calcium entry. 
  • Subtypes M2, M also increase the activity of phospholipase A2. In signal transduction from the b-adrenergic receptor G proteins .
  • Acetylcholine’s most prominent role is in neuromuscular transmission, where it is an excitatory transmitter.
  •  It is known that acetylcholine can have both excitatory and inhibitory effects. This depends on the nature of the ion channel, which it regulates when interacting with the corresponding receptor.

The acetylcholine muscarinic receptor belongs to the class of serpentine receptors that transmit signal through heterotrimeric G proteins . The muscarinic receptor family Their ability to bind the alkaloid muscarine . muscarinic receptors were initially divided pharmacologically into M1 and M2 types, based on differences in their sensitivity to pirenzepine . Which has proven to be a selective M1 receptor antagonist.  It has been shown that stimulation The…

The acetylcholine muscarinic receptor belongs to the class of serpentine receptors that transmit signal through heterotrimeric G proteins . The muscarinic receptor family Their ability to bind the alkaloid muscarine . muscarinic receptors were initially divided pharmacologically into M1 and M2 types, based on differences in their sensitivity to pirenzepine . Which has proven to be a selective M1 receptor antagonist.  It has been shown that stimulation The…